S100 Proteins As an Important Regulator of Macrophage Inflammation

S100 Proteins As an Important Regulator of Macrophage Inflammation

Blog Article

The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, Vitamin B proliferation, differentiation, energy metabolism, and inflammation.The intracellular functions of S100 proteins involve interaction with intracellular receptors, membrane protein recruitment/transportation, transcriptional regulation and integrating with enzymes or nucleic acids, and DNA repair.The S100 proteins could also be released from TAURINE the cytoplasm, induced by tissue/cell damage and cellular stress.

The extracellular S100 proteins, serving as a danger signal, are crucial in regulating immune homeostasis, post-traumatic injury, and inflammation.Extracellular S100 proteins are also considered biomarkers for some specific diseases.In this review, we will discuss the multi-functional roles of S100 proteins, especially their potential roles associated with cell migration, differentiation, tissue repair, and inflammation.